From Jessica Chastain and Oscar Isaac to Bradley Cooper and Lady Gaga, here's a round-up of some celebrity duos with undeniable chemistry both on and off-screen.&nbsp;

<a href="https://www.lofficielusa.com/film-tv/jessica-chastain-movies-interview-eyes-of-tammy-faye-scenes-from-a-marriage" target="_blank" rel="noopener">Jessica Chastain</a> and Oscar Isaac's recent <a href="https://www.lofficielusa.com/pop-culture/jessica-chastain-oscar-isaac-red-carpet-viral-moment-scenes-from-a-marriage" target="_blank" rel="noopener">red carpet appearance</a> at the <a href="https://www.lofficielusa.com/fashion/venice-film-festival-2021-red-carpet-fashion-spencer-house-of-gucci" target="_blank" rel="noopener">Venice Film Festival</a> sparked an Internet frenzy like no other. The duo's public display of affection left social media users in a daze, leading to numerous posts examining their relationship with one another. Despite their undeniable chemistry, especially in their new HBO miniseries Scenes from a Marriage, both Chastain and Isaac are happily married to other people.&nbsp;

The response to the pair's red carpet embrace strongly mirrored that of Bradley Cooper and Lady Gaga during their press tour for <a href="https://www.lofficielusa.com/music/the-shallow-a-star-is-born-2018" target="_blank" rel="noopener">A Star Is Born</a>.&nbsp;Given the nature of actors playing up their chemistry to promote new projects, L'OFFICIEL&nbsp;rounds up some celebrity pairs whose chemistries were off the charts, leading the public to wonder if it was just for the press, or if there's something secretly there.&nbsp;

Probably the biggest example of them all, Bradley Cooper and <a href="https://www.lofficielusa.com/fashion/lady-gaga-summer-2021-looks-valentino-dresses" target="_blank" rel="noopener">Lady Gaga</a> sparked a lot of conversation about their intense on-screen chemistry while promoting A Star Is Born in 2018. The romance rumors came to an all-time high after their iconic <a href="https://www.youtube.com/watch?v=JPJjwHAIny4" target="_blank" rel="noopener">performance</a> at the <a href="https://www.lofficielusa.com/fashion/best-dressed-oscars-2019" target="_blank" rel="noopener">2019 Academy Awards</a>.&nbsp;
However, the pair's relationship with one another is nothing more than a beautiful friendship. During the course of the film, Cooper had been in a four-year relationship with supermodel <a href="https://www.lofficielusa.com/pop-culture/irina-shayk-rare-facts-kanye-west-bradley-cooper" target="_blank" rel="noopener">Irina Shayk</a>, with whom he shares a daughter. Gaga has also publicly denied rumors of the two of them, stating how their love story was "<a href="https://www.elle.com/culture/music/a29683686/lady-gaga-haus-laboratories-elle-interview/" target="_blank" rel="noopener">orchestrated as a performance.</a>"&nbsp;

Following the release of the first film in the <a href="https://www.lofficielusa.com/film-tv/valentines-day-rom-com-movies-to-watch" target="_blank" rel="noopener">To All The Boys I've Loved Before</a> series, it seemed obvious that <a href="https://www.lofficielusa.com/film-tv/interview-lana-condor-to-all-the-boys" target="_blank" rel="noopener">Lana Condor</a> and <a href="https://www.lofficielusa.com/film-tv/internet-boyfriend-syndrome-female-driven-stories-bridgerton-rege-jean-page-noah-centineo-netflix" target="_blank" rel="noopener">Noah Centineo</a> could potentially have something between them off-screen, given the immense amount of chemistry they shared on screen. However, these were nothing but rumors, as Condor has been in a relationship with fellow actor Anthony De La Torre since 2015.&nbsp;
While Condor has admitted to having a crush on her co-star, she has made it clear that nothing has ever happened between the two of them. In fact, they made a real-life pact to keep things professional that mirrored the one in the films. "I felt that for the show to do well, we had to be best-friend professionals," she told <a href="https://www.youtube.com/watch?v=-s1xVDIfWJM&amp;lc=UgwXu94TFJtTfvthzSF4AaABAg" target="_blank" rel="noopener">Fallon</a> in 2019.&nbsp;

From&nbsp;The Wedding Singer (1998), 50 First Dates (2004), and Blended (2014), Adam Sandler and <a href="https://www.lofficielusa.com/fashion/drew-barrymore-style-evolution-90s-fashion-kids-husband" target="_blank" rel="noopener">Drew Barrymore</a> are definitely on the list for Hollywood's most iconic on-screen couples. Despite their chemistry, neither of the two has ever considered being in a romantic relationship.&nbsp;
"We always just hung out and had a good time. We always socialized, but we never, it's good," Sandler <a href="https://www.usmagazine.com/celebrity-news/news/drew-barrymore-adam-sandler-have-they-ever-dated-or-hooked-up-2014235/" target="_blank" rel="noopener">said</a> in 2014 during press for Blended. It's clear that the strong friendship they share with one another has made their on-screen relationship blossom.&nbsp;

Chris Evans and Scarlett Johansson

Fans have been obsessing over the relationship between Marvel's Natasha Romanoff and Steve Rogers for years. While working together in The Perfect Score (2004), The Nanny Diaries (2007), and several films in the Marvel Cinematic Universe, <a href="https://www.lofficielusa.com/beauty/scarlett-johansson-launching-skincare-beauty-brand" target="_blank" rel="noopener">Scarlett </a><a href="https://www.lofficielusa.com/beauty/scarlett-johansson-launching-skincare-beauty-brand" target="_blank" rel="noopener">Johansson</a> credits her on-screen chemistry with Chris Evans to their longtime friendship with one another.
"It&rsquo;s really a result of 10 years of knowing somebody and being able to have a kind of intimacy with them that you get from just spending a lot of time with somebody and knowing their soft underbelly," she said to <a href="https://ew.com/movies/2020/03/10/scarlett-johansson-black-widow-best-scenes/" target="_blank" rel="noopener">Entertainment Weekly</a> during press for&nbsp;<a href="https://www.lofficielusa.com/film-tv/scarlett-johansson-sues-disney-lawsuit-black-widow-movie-release" target="_blank" rel="noopener">Black Widow</a>. Despite having known each other for over a decade, the duo has only ever been friends. Johansson secretly married Saturday Night Live&nbsp;star Colin Jost in October 2020 and <a href="https://www.lofficielusa.com/pop-culture/scarlett-johansson-pregnant-husband-colin-jost-confirms" target="_blank" rel="noopener">welcomed a baby boy</a> last month.&nbsp;

There was electric chemistry between Sandra Bullock and <a href="https://www.lofficielusa.com/men/young-keanu-reeves-best-moments-the-matrix-90s" target="_blank" rel="noopener">Keanu Reeves</a> in the 1994 film&nbsp;Speed. While the two never dated, both parties have admitted to having secret crushes on one another in separate appearances on Ellen.&nbsp;
&ldquo;I think about how sweet Keanu Reeves was and how handsome he was,&rdquo; Bullock <a href="https://www.youtube.com/watch?v=qdjzr3QCKF4" target="_blank" rel="noopener">shared</a> in 2018 about working on Speed. &ldquo;It was hard. It was really hard for me to really be serious. He&rsquo;d look at me and I&rsquo;d [giggle].&rdquo; Following this interview, Reeves <a href="https://www.youtube.com/watch?v=waY6FwOd9eM" target="_blank" rel="noopener">shared</a> his reciprocated crush in 2019, stating that &ldquo;she obviously didn&rsquo;t know I had a crush on her, either.&rdquo; Unfortunately, Bullock has been in a relationship with photographer Bryan Randall since 2015, while Reeves has been dating artist Alexandra Grant since 2018.&nbsp;

Kate Hudson and Matthew McConaughey

<span style="background-color: transparent; font-family: inherit; font-size: inherit; font-style: inherit; font-variant-ligatures: inherit; font-variant-caps: inherit; font-weight: inherit; letter-spacing: 0px;">From&nbsp;How To Lose A Guy In Ten Days&nbsp;(2003) to&nbsp;Fools Gold&nbsp;(2008), <a href="https://www.lofficielusa.com/pop-culture/celebrities-you-didnt-know-famous-moms" target="_blank" rel="noopener">Kate Hudson</a> and <a href="https://www.lofficielusa.com/politics-culture/celebrities-in-politics-caitlyn-jenner-kanye-west-cynthia-nixon" target="_blank" rel="noopener">Matthew McConaughey</a> is another important addition to Hollywood's most iconic on-screen couples.&nbsp;
<span style="background-color: transparent; font-family: inherit; font-size: inherit; font-style: inherit; font-variant-ligatures: inherit; font-variant-caps: inherit; font-weight: inherit; letter-spacing: 0px;">During his <a href="https://www.youtube.com/watch?v=vVkDI9pwvPs" target="_blank" rel="noopener">#</a><a href="https://www.youtube.com/watch?v=vVkDI9pwvPs" target="_blank" rel="noopener">McConaugheyTakes</a> series, the actor explained that the most important factor to filming romantic comedies is the connection needed between the actors.&nbsp;<span style="background-color: transparent; font-family: inherit; font-size: inherit; font-style: inherit; font-variant-ligatures: inherit; font-variant-caps: inherit; font-weight: inherit; letter-spacing: 0px;">&ldquo;Kate and I had great chemistry, obviously we worked after that on other films. But we had a really good push and pull,&rdquo; he said. &ldquo;She had a lot of rock 'n' roll and I did too, the way we would parry with each other really worked in that film.&rdquo;
<span style="background-color: transparent; font-family: inherit; font-size: inherit; font-style: inherit; font-variant-ligatures: inherit; font-variant-caps: inherit; font-weight: inherit; letter-spacing: 0px;">Despite the duo's great chemistry with each other, the romance ended on screen. Both parties were in relationships while working together. Hudson was married to Chris Robinson from 2000 to 2007, and McConaughey has been married since 2012 and shares three kids with his wife Camile Alves.&nbsp;

Celebrity Co-Stars With Endless Chemistry

Tags

Related Articles

Pop culture

Jessica Chastain and Oscar Isaac's Red Carpet Embrace Goes Viral

Film & TV

Jessica Chastain Covers L'OFFICIEL's Centennial Issue

Music

Gaga and Bradley Cooper Go Deep in "The Shallow"

Recommended posts for you

Fashion

Van Cleef & Arpels Charts 'Treasure Island' in New High Jewelry Collection

Pop culture

7 Things To Know About 'Emily in Paris' Star Philippine Leroy-Beaulieu

Fashion

An Inside Look at Thom Browne’s 10,000 Hour Creations for Ariana Grande and Cynthia Erivo

Beauty

Spring/Summer 2025 Hair Trends: The Best Looks Straight From the Runway

Pop culture

Charli XCX Takes on New York in Style Ahead of Saturday Night Live

Pop culture

F1's Hottest Drivers, On and Off The Track

Fashion

New NYC Store Openings in 2024

Film & TV

Everything to Know About the New 'Dune' TV Series, a Must-Watch